Modi Ventures is a Houston-based venture capital firm founded in 2022 by Sahir Ali. The firm specializes in investing at the convergence of artificial intelligence, biology, and medical technology. Positioned at the heart of the Texas Medical Center’s TMC Helix Park, Modi Ventures focuses on building and funding companies that are pushing the boundaries of digital biology, therapeutics, and next-generation healthcare.
Modi Ventures backs early-stage companies operating at the intersection of AI and life sciences.
Its key focus areas include:
The firm invests both directly in companies and selectively through other high-conviction venture funds that align with its scientific and technical thesis.
In July 2025, Modi Ventures closed its second fund at $88 million, bringing its total committed capital to over $134 million. Fund II continues the firm’s mission of supporting startups that are transforming medicine and biology through AI.
Leadership
Modi Ventures is led by Sahir Ali, a solo general partner with a background in venture capital and deep interest in computational biology and emerging healthcare technologies.
From its base at the Texas Medical Center’s Helix Park campus, the firm benefits from proximity to a world-class biomedical research ecosystem, offering access to talent, clinical partners, and scientific breakthroughs.
Investment Strategy
The firm’s strategy centers on identifying and backing transformational technologies at the convergence of AI and biological sciences.
Modi Ventures deploys capital into both startups and venture funds, positioning itself as a hybrid builder and enabler of the next generation of life science innovation. It looks for platform technologies with the potential for deep biological insights and broad therapeutic applications. The firm maintains a lean, founder-centric approach with high conviction bets on science-driven companies.
Notable Investments
Initial investments from Fund II include:
Other notable portfolio holdings include:
Modi Ventures has also invested in funds managed by firms such as Khosla Ventures, Section 32, Artis Ventures, Draper Associates, Yosemite, and Abingworth.
Notable Exits
No exits have been reported to date for Modi Ventures, as the firm is still in the early stages of deployment and growth across its initial portfolio.
Other
Operating from the TMC Helix Park campus provides Modi Ventures with unique exposure to one of the world’s largest medical innovation ecosystems.
The firm’s combined direct and indirect investment strategy allows it to support company creation while benefiting from insights and deal flow across top-tier scientific venture funds.
Its founder, Sahir Ali, is among a new wave of solo GPs driving specialized, thesis-driven venture models in frontier science.
