Portfolia is a San Mateo, California–based venture investing platform founded to engage women as leading venture investors and to back high-potential companies addressing unmet needs in health and innovation. Since its launch, the firm has built a reputation as the most active women’s health investor in the United States, combining capital with community to scale solutions that directly impact women’s lives.
Portfolia invests in early- to growth-stage companies across health and technology, with a distinctive emphasis on women’s health. Its strategy focuses on three major categories:
In August 2025, Portfolia launched Women’s Health Fund IV, open to accredited investors, qualified purchasers, and family offices. The fund builds on the success of three prior women’s health vehicles, establishing Portfolia as the most active investor in this category in the U.S. To date, the firm has completed 46 health-related investments across fertility, childbirth, menopause, autoimmune disease, oncology, cardiovascular health, mental health, nutrition, and longevity.
The first investment from Women’s Health Fund IV is in Gameto, a clinical-stage biotechnology company reprogramming female cells to transform fertility and hormonal care. With its fourth fund, Portfolia continues to expand its position as a specialized leader in women’s health, targeting innovations with both high impact and strong return potential.
Leadership
The firm was founded and is led by Trish Costello, Founder and CEO. The leadership team for Women’s Health Fund IV also includes notable partners such as Nola Masterson, Faz K. Bashi, Sonia Arrison, Jennifer Fried, and Delphine O’Rourke, each bringing a combination of healthcare, biotech, venture capital, and policy expertise.
Investment Strategy
Portfolia operates a distinctive model that combines professional investment management with a community of engaged women investors. This strategy allows the fund to source and support companies tackling women’s health challenges while also democratizing access to venture investing for women. The investment approach prioritizes companies with scalable health innovations, clear clinical impact, and commercial growth potential across early- and growth-stage development.
Notable Investments
Portfolia’s prior funds have backed companies that have become leaders in women’s health innovation. These include:
Each represents a major advance in areas ranging from fertility and childbirth to oncology, diagnostics, and digital health platforms.
Notable Exits
Several of Portfolia’s portfolio companies have achieved significant growth and recognition, with Maven Clinic and EverlyHealth standing out as high-profile examples. Publicly disclosed exits remain limited, with many investments still in growth and clinical development phases.
Other
Portfolia stands out not only as an active investor in women’s health but also as a movement to reshape venture capital by engaging women as LPs and decision-makers. Founders backed by Portfolia gain access to a highly engaged investor community and a firm with a proven track record in health innovation.
