A100x Ventures is a New York-based early-stage venture capital firm founded in 2021, co-led by managing partners Nisa Amoils and Sal Ternullo. The firm specializes in backing pre-seed and seed-stage startups operating at the intersection of artificial intelligence and blockchain technologies. A100x is known for its thesis-driven approach, focusing on real-world applications that leverage emerging technologies to reshape industries.
In May 2025, A100x Ventures announced the closing of its second fund, securing $50 million in commitments from institutional investors, family offices, and high-net-worth individuals.
Fund II is dedicated to supporting pre-seed and seed-stage founders developing applications and middleware that integrate AI and blockchain technologies. The fund aims to invest in startups that are creating solutions to real-world problems, with a focus on fostering enterprise and consumer adoption.
Leadership
A100x Ventures' team brings a diverse background in venture capital, law, and financial services. Managing Partner Nisa Amoils has over 13 years of experience in venture investing and is recognized as a leading figure in the blockchain and AI investment space. Sal Ternullo, also a Managing Partner, has a decade of experience in financial services and web3, previously operating an early-stage web3 venture fund. The firm's approach emphasizes active collaboration with founders, providing strategic support beyond capital.
Notable Investments
A100x Ventures has invested in a range of early-stage companies, including Station70, a firm focused on digital asset security solutions.
The firm continues to seek out startups that are developing innovative applications at the intersection of AI and blockchain technologies.
United States
