A100x Ventures is a New York-based early-stage venture capital firm founded in 2021, co-led by managing partners Nisa Amoils and Sal Ternullo. The firm specializes in backing pre-seed and seed-stage startups operating at the intersection of artificial intelligence and blockchain technologies. A100x is known for its thesis-driven approach, focusing on real-world applications that leverage emerging technologies to reshape industries.
A100x invests in early-stage companies that harness the convergence of AI and blockchain to develop solutions in areas such as decentralized finance (DeFi), digital identity, and enterprise infrastructure.
The firm seeks founders who are building middleware and applications aimed at solving real-world challenges and fostering enterprise and consumer adoption of these technologies.
In May 2025, A100x Ventures announced the closing of its second fund, securing $50 million in commitments from institutional investors, family offices, and high-net-worth individuals.
Fund II is dedicated to supporting pre-seed and seed-stage founders developing applications and middleware that integrate AI and blockchain technologies. The fund aims to invest in startups that are creating solutions to real-world problems, with a focus on fostering enterprise and consumer adoption.
Leadership
A100x Ventures' team brings a diverse background in venture capital, law, and financial services. Managing Partner Nisa Amoils has over 13 years of experience in venture investing and is recognized as a leading figure in the blockchain and AI investment space. Sal Ternullo, also a Managing Partner, has a decade of experience in financial services and web3, previously operating an early-stage web3 venture fund. The firm's approach emphasizes active collaboration with founders, providing strategic support beyond capital.
Notable Investments
A100x Ventures has invested in a range of early-stage companies, including Station70, a firm focused on digital asset security solutions. The firm continues to seek out startups that are developing innovative applications at the intersection of AI and blockchain technologies.
