Portal Innovations is a Chicago-based venture capital firm founded in 2020 to back life sciences companies emerging from regions rich in scientific talent but underserved by venture capital and specialized lab facilities.
The firm targets early-stage life sciences companies across biotech, therapeutics, diagnostics, and related technologies, often linked to local research institutions.
In August 2025, Portal Innovations began raising a USD 100 million life sciences fund. The firm is also collaborating with universities to establish startup incubators as institutions seek alternatives to diminishing federal research support.
Portal operates lab facilities in Chicago, Atlanta, Houston, and a Boston neighborhood outside the core life sciences cluster.
Leadership
Portal Innovations is led by founder and CEO John Flavin, who brings extensive experience across biotech entrepreneurship and facility development.
Investment Strategy
The strategy couples early-stage capital with purpose-built laboratory infrastructure and operational support.
By partnering with universities and real-estate developers, the firm accelerates the path from academic research to commercially viable startups.
Notable Investments
Specific portfolio details are not disclosed in the fund announcement, though the firm backs companies that emerge from its lab network and academic partnerships.
Notable Exits
There are no publicly disclosed notable exits at this stage.
